Toby Dylan Hocking | Publications

My pages on Google Scholar and Mathematics Genealogy Project.
Peer review notice: in addition to peer-reviewed journals, I publish papers at machine learning conferences such as ICML and NIPS, which have double-blind peer reviews, and only accept about 20% of submitted papers.
Reproducible Research notice: a “Reproducible” link for each paper below provides source code and data that I used to perform the analysis and make the figures/tables.
Software notice: a “Software” link for each paper below provides a software package with a reference implementation of the algorithms described in our paper.
Selected publications in bib format.

Hocking TD. Regular expressions and reshaping using data tables and the nc package. Under review at R Journal. Software, Reproducible
Hocking TD, Rigaill G, Fearnhead P, Bourque G. Constrained dynamic programming and supervised penalty learning algorithms for peak detection in genomic data. Preprint arXiv:1703.03352. Under review at Journal of Machine Learning Research. Software, Reproducible
Hocking TD, Rigaill G, Fearnhead P, Bourque G. Generalized Functional Pruning Optimal Partitioning (GFPOP) for Constrained Changepoint Detection in Genomic Data. Preprint arXiv:1810.00117. Under review at Journal of Statistical Software. Software, Reproducible. Presentation at useR 2020: slides, video.
Venuto D, Hocking TD, Spanurattana S, Sugiyama M. Support vector comparison machines. Preprint arXiv:1401.8008. Under review at Journal of Machine Learning Research. Software, Reproducible
Hocking TD, Khare A. Learning penalty functions for changepoint detection using elastic-net regularized accelerated failure time models. Software, Reproducible

Hocking TD, Bourque G. Machine Learning Algorithms for Simultaneous Supervised Detection of Peaks in Multiple Samples and Cell Types. Pacific Symposium on Biocomputing 25:367-378. PDF, Software

Hocking TD. Comparing namedCapture with other R packages for regular expressions. Accepted for publication in R Journal. Software, Reproducible
Jewell S, Hocking TD, Fearnhead P, Witten D. Fast Nonconvex Deconvolution of Calcium Imaging Data. Biostatistics (2019), doi: 10.1093/biostatistics/kxy083. pubmed

Depuydt P, Koster J, Boeva V, Hocking TD, Speleman F, Schleiermacher G, De Preter K. Meta-mining of copy number profiles of high-risk neuroblastoma tumors. Scientific Data (2018).
Alirezaie N, Kernohan KD, Hartley T, Majewski J, Hocking TD. ClinPred: Prediction Tool to Identify Disease-Relevant Nonsynonymous Single-Nucleotide Variants. American Journal of Human Genetics (2018). doi:10.1016/j.ajhg.2018.08.005 AJHG, Software.
Sievert C, Cai J, VanderPlas S, Ferris K, Khan FUF, Hocking TD. Extending ggplot2 for linked and animated web graphics. Journal of Computational and Graphical Statistics (2018). doi:10.1080/10618600.2018.1513367. JCGS, Software, Reproducible, Interactive Figures.
Depuydt P, Boeva V, Hocking TD, Cannoodt R, Ambros IM, Ambros PF, Asgharzadeh S, Attiyeh EF, Combaret V, Defferrari R, Fischer M, Hero B, Hogarty MD, Irwin MS, Koster J, Kreissman S, Ladenstein R, Lapouble E, Laureys G, London WB, Mazzocco K, Nakagawara A, Noguera R, Ohira M, Park JR, Pötschger U, Theissen J, Tonini GP, Valteau-Couanet D, Varesio L, Versteeg R, Speleman F, Maris JM, Schleiermacher G, De Preter K. Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients. Journal of the National Cancer Institute (2018). DOI:10.1093/jnci/djy022. JNCI

Drouin A, Hocking TD, Laviolette F. Maximum margin interval trees. Neural Information Processing Systems (NIPS) 2017. Software, Reproducible, arXiv, NIPS, video
Hocking TD, Goerner-Potvin P, Morin A, Shao X, Pastinen T, Bourque G. Optimizing ChIP-seq peak detectors using visual labels and supervised machine learning. Bioinformatics (2017) 33 (4): 491-499. pubmed, Software, Reproducible

Shimada K, Shimada S, Sugimoto K, Nakatochi M, Suguro M, Hirakawa A, Hocking TD, Takeuchi I, Tokunaga T, Takagi Y, Sakamoto A, Aoki T, Naoe T, Nakamura S, Hayakawa F, Seto M, Tomita A, Kiyoi H. Development and analysis of patient-derived xenograft mouse models in intravascular large B-cell lymphoma. Leukemia 2016. pubmed
Chicard M, Boyault S, Colmet-Daage L, Richer W, Gentien D, Pierron G, Lapouble E, Bellini A, Clement N, Iacono I, Bréjon S, Carrere M, Reyes C, Hocking TD, Bernard V, Peuchmaur M, Corradini N, Faure-Conter C, Coze C, Plantaz D, Defachelles A-S, Thebaud E, Gambart M, Millot F, Valteau-Couanet D, Michon J, Puisieux A, Delattre O, Combaret V, Schleiermacher G. Genomic copy number profiling using circulating free tumor DNA highlights heterogeneity in neuroblastoma. Clinical Cancer Research 2016. journal
Maidstone R, Hocking TD, Rigaill G, Fearnhead P. On optimal multiple changepoint algorithms for large data. Statistics and Computing (2016). doi:10.1007/s11222-016-9636-3 journal, Software, Reproducible

Hocking TD, Rigaill G, Bourque G. PeakSeg: constrained optimal segmentation and supervised penalty learning for peak detection in count data. International Conference on Machine Learning (ICML), 2015. PMLR, video, Software, Reproducible
Hocking TD. A breakpoint detection error function for segmentation model selection and validation. Preprint arXiv:1509.00368, Software, Reproducible
Hocking TD, Bourque G. PeakSegJoint: fast supervised peak detection via joint segmentation of multiple count data samples. Preprint arXiv:1506.01286, Software, Reproducible

Suguro M, Yoshida N, Umino A, Kato H, Tagawa H, Nakagawa M, Fukuhara N, Karnan S, Takeuchi I, Hocking TD, Arita K, Karube K, Tsuzuki S, Nakamura S, Kinoshita T, Seto M. Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis. Cancer Sci. 2014 Jul;105(7):897-904. pubmed
Hocking TD, Boeva V, Rigaill G, Schleiermacher G, Janoueix-Lerosey I, Delattre O, Richer W, Bourdeaut F, Suguro M, Seto M, Bach F, Vert J-P. SegAnnDB: interactive Web-based genomic segmentation. Bioinformatics (2014) 30 (11): 1539-1546. DOI:10.1093/bioinformatics/btu072 pubmed, Software, Reproducible

Hocking TD, Wutzler T, Ponting K and Grosjean P. Sustainable, extensible documentation generation using inlinedocs. Journal of Statistical Software (2013), 54(6), 1-20. DOI:10.18637/jss.v054.i06 journal, Software, Reproducible
Hocking TD, Schleiermacher G, Janoueix-Lerosey I, Boeva V, Cappo J, Delattre O, Bach F, Vert J-P. Learning smoothing models of copy number profiles using breakpoint annotations. BMC Bioinfo. 2013, 14:164. DOI:10.1186/1471-2105-14-164 journal, Software, Reproducible
Hocking TD, Rigaill G, Bach F, Vert J-P. Learning sparse penalties for change-point detection using max-margin interval regression. International Conference on Machine Learning (ICML), 2013. PMLR, video Software, Reproducible

Hocking TD, Rigaill G. SegAnnot: an R package for fast segmentation of annotated piecewise constant signals, Preprint hal-00759129. Software, Reproducible
Hocking TD. Learning algorithms and statistical software, with applications to bioinformatics. PhD thesis, Ecole Normale Superieure de Cachan, France. tel-00906029, Reproducible

Hocking TD, Joulin A, Bach F, Vert J-P. Clusterpath: an Algorithm for Clustering using Convex Fusion Penalties. International Conference on Machine Learning (ICML), 2011. pdf, video Software, Reproducible

Gautier M, Hocking TD, Foulley JL. A Bayesian outlier criterion to detect SNPs under selection in large data sets. PloS ONE 5 (8), e11913 (2010). journal

Doyon Y, McCammon JM, Miller JC, Faraji F, Ngo C, Katibah GE, Amora R, Hocking TD, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Amacher SL. Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases. Nature biotechnology 26 (6), 702-70 (2008). pubmed